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Flaxseed allergy cross reactivity8/10/2023 ![]() I might mention parenthetically that sesame seed has been shown to cross-react with other foods including kiwi, rye, hazelnut, black walnut, macadamia, cashew, pistachio, and peanuts. Three patients who experienced IgE-mediated reactions to poppy also showed positive serologic testing to sesame. In terms of seeds, sesame has been shown to cross-react with poppy seed (1). In vitro cross-reactivity between sesame and a number of other foods has been demonstrated. Perhaps the largest body of literature looking at the seeds mentioned relates to sesame seed. I will share with you what I have been able to find in this regard. However, there are some in vitro studies which have looked at allergens contained in seeds from the standpoint of their potential cross-reactivity. "Īs you can see from these two reviews of cross-reaction between foods, there are little clinically significant data that would allow us to answer your question definitively. "Seed storage proteins 2S, 7S and 11S: limited level of cross-reactivity between foods? Seed storage proteins 2S albumin, 7S vicilin and 11S legumin have been identified as the major allergens in legumes like peanut, soy and lentils, but also in tree nuts and other seeds like sesame and sunflower. Current Opinion in Allergy and Clinical Immunology 2004 4:235-240) also had very little to say on this subject, mentioning only the following in regards to cross-reactivity between seeds: ![]() Clinical importance of cross-reactivity in food allergy. This article, even though written in 2001, still remains a valid source of information, and according to my search of the literature, very little has been added to the literature regarding this subject since that time.Ī slightly more recent review on cross-reactivity to food (van Ree, R. Clinical implications of cross-reactive food allergens. A case of sesame seed-induced anaphylaxis. Asero R, Mistrello G, Roncarolo D, Antoniotti PL, Falagiani P. Common allergenic structures in hazelnut, rye grain, sesame seeds, kiwi, and poppy seeds. Vocks E, Borga A, Szliska C, Seifert HU, Burow G, Borelli S. "Reactions to seeds, such as sesame, mustard, and poppy, are reported (27, 35, 36) andĬross-reactivity with foods (hazel, kiwi, and other seeds) and pollens is potentially important, but the full clinical implications are far from established. Sicherer's superb and comprehensive article on the clinical significance of cross-reactivity between foods, which is: What is the current data regarding cross-reactivity of seeds (sesame, mustard, sunflower, and poppy)? If a toddler has a history and testing positive for an allergy to one seed, should testing for other seed allergies be considered? How accurate is ImmunoCap blood testing for seeds?Ī: I am going to preface my answer to your question with a quote from Dr. ![]() ![]() In summary, I am not able to help you in your advising patients except the concern about poppy and sesame and possibly mustard and sunflower. I searched the Allergome data base and the information I found was related to inhalant allergens, as you indicated. Poppy and sesame and mustard and sunflower may cross react (see below). However, the clinical evidence of the importance of this cross-reactivity is not well substantiated. The 2S, 7S, 11S storage proteins are common to many seeds and could provide cross reactivity. I think your summary of the literature suggesting that we do not have a great deal of detail on the cross reactivity of ingested seeds is a fair assessment.
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